Equivalent asthma control after dose reduction with HFA-134a beclomethasone solution aerosol

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Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone.

Hydrofluoroalkane-134a (HFA) beclomethasone dipropionate (BDP) was formulated in a metered-dose inhaler (MDI) to deliver a particle size of 1.1 microm compared with 35 microns for currently marketed chlorofluorocarbon (CFC)-BDP products. Two phase I single-dose human deposition studies were conducted using technetium 99m-radiolabelled BDP in a press-and-breathe actuator without an add-on spacer...

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ژورنال

عنوان ژورنال: Respiratory Medicine

سال: 2000

ISSN: 0954-6111

DOI: 10.1053/rmed.1999.0772