Equivalent asthma control after dose reduction with HFA-134a beclomethasone solution aerosol

Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone.

Hydrofluoroalkane-134a (HFA) beclomethasone dipropionate (BDP) was formulated in a metered-dose inhaler (MDI) to deliver a particle size of 1.1 microm compared with 35 microns for currently marketed chlorofluorocarbon (CFC)-BDP products. Two phase I single-dose human deposition studies were conducted using technetium 99m-radiolabelled BDP in a press-and-breathe actuator without an add-on spacer...

Beclomethasone aerosol in childhood asthma.

Godfrey, S., and Konig, P. (1973). Archives of Disease in Childhood, 48, 665. Beclomethasone aerosol in childhood asthma. Twenty children have been treated with the steroid aerosol beclomethasone, half of them in an open trial and the other half in a controlled cross-over trial. Children were assessed by means of clinical examination, diary records, and twice-daily peak flow rate measurements m...

Improved control of asthma symptoms with a reduced dose of HFA-BDP extrafine aerosol: an open-label, randomised study.

BACKGROUND Extrafine aerosols may improve asthma symptom control through increased lung deposition of medication to inflamed peripheral airways. METHODS The effect of switching patients with asthma maintained on up to 2000 microg/day chlorofluorocarbon-beclomethasone dipropionate (CFC-BDP), 1600 microg/day budesonide, 1000 microg/day fluticasone, or 2000 microg/day flunisolide, to a reduced d...

Beclomethasone dipropionate aerosol in childhood asthma.

A comparison of HFA-BDP Autohaler with budesonide Turbuhaler in asthma control of adult patients with mild to moderately severe disease.

Hydrofluoroalkane-134a (HFA) beclomethasone dipropionate (BDP) extrafine aerosol is a pressurized metered dose inhaler (pMD1) available for the treatment of asthma. Unlike most pMDIs, HFA-BDP is a solution, rather than a suspension, of BDP in HFA propellant. This reforrnulation, combined with improvements in inhaler technology, results in the production of aerosol particles of smaller mean mass...